Tayseer A. Abdallah
Jul 1, 2007
Citations
0
Influential Citations
21
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
2-Oxo-3-(indol-3-yl)propanonitrile 2 condensed with dimethylformamide dimethylacetal to yield the enaminonitrile 3. The latter reacted with 4-chloroaniline to yield the 4-chlorophenylaminoacrylonitrile 5. Reaction of 3 with hydrazine hydrate led to formation of pyrazole-4-carbonitrile 6. Compound 3 reacted with ethyl acetoacetate in refluxing acetic acid and in presence of ammonium acetate to yield the indolylpyridine 10. Enamine 3 reacted with 5(1H)-aminotriazole 13 and 3(5)-aminopyrazole 17 to yield the pyrimidine derivatives 15 and 19, respectively.