Sudip Pal, U. Ghosh, R. Ampapathi
2015
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Abstract
Gramicidin S, the most notable example of cationic antimicrobial peptides (CAPs), has remained in the forefront of worldwide research for development of new antibiotics for over seven decades now. Hundreds of papers have been published over the years on this molecule and its numerous analogs, delineating their structures and biological activities with an aim to achieve selective antimicrobial activities with reduced cytotoxicity for potential therapeutic applications. The present review attempts to capture the essence of some of the recent studies with the aims to chronicle the journey traversed by this fascinating molecule so far and to decipher what is needed for future success.