H. Maruoka, K. Yamagata, M. Yamazaki
Dec 13, 1993
Citations
0
Influential Citations
10
Citations
Journal
European Journal of Organic Chemistry
Abstract
The reaction of 2-amino-4,5-dihydro-3-thiophenecarbonitriles 1a–c with ethyl acetoacetate in the presence of titanium(IV) chloride gave the corresponding ethyl 4-amino-2,3-dihydro-6-methylthieno[2,3-b]pyridine-5-carboxylates 3a–c. Similarly, compounds 1a–c reacted with diethyl malonate or ethyl cyanoacetate to give the corresponding ethyl 4-amino-2,3,6,7-tetrahydro-6-oxothieno[2,3-b]pyridine-5-carboxylates 4a–c or ethyl 4,6-diamino-2,3-dihydrothieno[2,3-b]pyridine-5-carboxylates 5a–c.