M. J. Finn, M. A. Harris, E. Hunt
Sep 18, 1984
Citations
1
Influential Citations
28
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
1-Amino-4-hydroxybutan-2-one (14) has been identified as one of the major products from the hydrolysis of clavulanic acid in acidic, alkaline, or neutral solution. In alkaline or neutral solution, the amino ketone (14) is converted into other products, including two pyrazines, 2,5-bis(2-hydroxyethyl)pyrazine and 3-ethyl-2,5-bis(2-hydroxyethyl)pyrazine. A rationale for the formation of these products is discussed.