J. Genest, G. Dufault, G. Pigeon
Apr 23, 1960
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Journal
Canadian Medical Association journal
Abstract
TREATMENT OF arterial hypertension has been in constant progress since the discovery of the hypotensive effects of hexamethonium by Paton and Zaimis in 1948.1 In May 1959, a new drug, bretylium tosylate, became available for clinical evaluation in patients with arterial hypertension. Results obtained indicate that this new sympathetic blocking drug constitutes an important improvement in the medical treatment of hypertension because of its effectiveness and the almost complete absence of parasympathetic blocking action. Bretylium tosylate is a benzyl quaternary ammonium compound (Fig. 1), synthetized by Bouira Canad. M. A. J. April 23, 1960, vol. 82