W. Prusoff
Sep 1, 1959
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0
Influential Citations
42
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract Azathymidine, an analogue of thymidine, inhibited reversibly the utilization of radioactive thymidine for the biosynthesis of DNA-thymine of Ehrlich ascites tumour cells in vitro . The thymidine analogue also inhibited the utilization of radioactive adenine for the biosynthesis of DNA-adenine, but an excess of thymidine did not completely prevent this inhibition. Deoxyadenosine, but not adenosine, adenine or deoxyguanosine, inhibited the utilization of formate and to a lesser extent that of thymidine for the biosynthesis of DNA-thymine.