J. Gumucio, V. Valdivieso
Sep 1, 1971
Citations
3
Influential Citations
130
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Quality indicators
Journal
Gastroenterology
Abstract
Ethynylestradiol was administered to female rats to determine the mechanism by which estrogens produce alterations in the hepatic excretion of organic anions. This was studied by administration through a gastric tube daily for 5 days in order to study its effect on bile flow and bile salt excretion. Bile was collected by cannulation of the common bile duct. Bile flow was significantly greater in the control group (p less than .01). Bile salt concentration was higher in the treated group (p. less than .025) although bile salt excretion was greater in the control rats. The overall difference were not statistically significant. Treatment with ethynylestradiol reduced the secretion of bile-salt independent fraction of bile water from 40.4% of the total bile flow to 26.6%. The results of carbon-14-erythritol clearances indicated that the inhibitory effect of ethynylestradiol on bile flow was on water secreted by the hepatocyle. The implications of this are discussed.