I. Iijima, J. Minamikawa, A. Jacobson
Apr 1, 1978
Citations
4
Influential Citations
145
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
(+)-Naloxone was prepared in 26% overall yield in eight steps from (+)-7-bromodihydrocodeinone dimethyl ketal by a synthesis which excluded enantiomeric contamination. (+)-Naloxone was examined in three assay systems and found to have no more than 1/1000(-1)/10 000th the activity of (-)-naloxone; it can, thus, serve to test the stereospecificity of the biochemical and pharmacological actions of (-)-naloxone.