S. Scheibye, A. El‐Barbary, S. Lawesson
1982
Citations
0
Influential Citations
37
Citations
Journal
Tetrahedron
Abstract
Abstract 4-Substituted-1,2-diphenyl-3,5-pyrazolidinediones (Phenylbutazone analogous) 1a–d react with 2,4-bi-(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-difulside (Lawesson Reagent (LR) with formation of the corresponding 3,3′-dithiobis (1,2-dihydro-3 H -pyrazole-5-thione)'s 2a–d . When the 4-substituent contains a sulfoxide group this is deoxygenated to the sulfide by LR at room tmeperature. 1-Phthalazinone-4-thione, 1,4-phthalazine-dithione and ethyl aminothioxoacetate have also been prepared from the corresponding carbonyl compounds. Alkylation or acylation of 2a–d yielded 3H-pyrazole-3-thione derivatives 8 and 9 . Alkylation of 1 with MeI in the presence of Et 3 N at room temp. yielded the C-alkylated products 10 exclusively. X-RAy crystallographic investigations of 2b and 9a are presented.