N. Mitsuyasu, S. Matsuura, M. Waki
Jun 1, 1970
Citations
0
Influential Citations
11
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
The synthesis of cyclic decapeptide, cyclo-L-phenylalanyl-D-phenylalanyl-L-asparaginyl-L-glutaminyl-L-phenylalanyl-L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl, which has the amino acid sequence designated as tyrocidine E by Kurahashi, and the chemical and biological properties of the synthetic product, have been described. The degree of the activity of the synthetic product toward the Gram positive microorganisms is nearly the same as that of tyrocidine A. The results indicate that the L-tyrosine residue in the molecule of tyrocidine A can be replaced by L-phenylalanine without influencing activity.