G. Somers
Mar 1, 1953
Citations
0
Influential Citations
11
Citations
Journal
British journal of pharmacology and chemotherapy
Abstract
Succinylcholine, a choline ester of succinic acid, is a short-acting neuromuscular relaxant. A review of its chemical, pharmacological, and clinical properties has been published elsewhere (Bourne, Collier, and Somers, 1952). Previous studies on the pharmacology of this compound have been largely confined to the dog and rabbit, and a closer study of its actions in the cat seemed desirable. Organe, Paton, and Zaimis (1949) showed that the actions anterior muscles, stimulated with supramaximal shocks applied to the peripheral end of the sciatic nerve in the thigh, were recorded with a flat spring myograph as described by Paton and Zaimis (1949). All injections were made intravenously and the doses recorded are those for succinylcholine chloride per kg. body weight. Salivary flow was recorded in three cats and two dogs, anaesthetized with chloralose, by a drop recorder (Gaddum and Kwiatkowski, 1938) after cannulation of Wharton's duct.