A. Pakrashi
Apr 1, 1967
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Journal
Indian journal of experimental biology
Abstract
The effect of byakangelicin on female sex hormones and on fertility of rats and rabbits was investigated. Intact and castrate albino rats received sc injections of 1-3 mg/day/rat for 6 days 3 days alone and 3 days with 5 IU estradiol. Immature rabbits received im injections of 50 IU of estrogen for 3 days followed by 3-6 mg of byakangelicin/day along with the same amount of hormone for 3 more days. The animals were sacrificed 24 hours after the last injection. Changes in gross uterine weight histological and histochemical examinations of tissues and vaginal smear test indicated that byakangelicin partially blocked the uterotropic respones of exogenous estrogen. No effect on the progesterone response of the uterus was seen. Byakangelicin caused irregularity of estrous cycle delay in mating and a marked decrease in fertile mating and in number of offspring. It appeared that byakangelicin might delay the sexual maturity of rats.