K. Sasajima, K. Ono, J. Katsube
Aug 25, 1978
Citations
0
Influential Citations
3
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
A new synthesis of 2'-amino-4'-fluoro-4-[4-hydroxy-4-(α, α, α-trifluoro-m-tolyl) piperidino] butyrophenone using a selective ortho-amination as a key step was described. The solvents and temperature effects on the selectivity for this ortho-amination of 2', 4'-difluoro-4-[4-hydroxy-4-(α, α, α-trifluoro-m-tolyl) piperidino] butyrophenone were investigated.