N. Patel, G. Barat
Apr 1, 2010
Citations
0
Influential Citations
13
Citations
Journal
Journal of Saudi Chemical Society
Abstract
Abstract A series of new 2-[2-(2,6-dichlorophenyl)amino]phenyl methyl-3-[(5-substituted phenyl)-1,5-dihydro-1 H -pyrazol-3-yl-amino]-6-iodoquinazolin-4(3 H ) ones ( 6a–m) have been synthesized by the reaction of 2-[2-(2,6-dichlorophenyl)amino]phenyl methyl-3-substituted phenyl acryl amido-6-iodoquinazolin-4(3 H ) ones with hydrazine hydrate in the presence of glacial acetic acid. The chalcone ( 5a–m) have been prepared by the condensation of 2-[2-(2,6-dichlorophenyl)amino]phenyl methyl-3-acetamido-6-iodoquinazolin-4(3 H ) one with different substituted aromatic aldehyde. The compound 1 on treatment with 5-iodoanthranilic acid in pyridine undergoes cyclisation gave 2-[2-(2,6-dichlorophenyl)amino]phenyl methyl-6-iodo-3,1-benzoxazin-4(3 H ) one ( 2). Treatment on benzoxazine with hydrazine hydrate gave 3-amino-2-[2-(2,6-dichlorophenyl)amino]phenyl methyl-6,8-dibromo quinazolin-4(3 H ) one ( 3) followed by acetylation synthesized 2-[2-(2,6-dichlorophenyl)amino]phenyl methyl-3-acetamido-6,8-dibromoquinazolin-4(3 H )-one ( 4) . The structure of synthesized compounds has been elucidated by IR, 1 H NMR, 13 C NMR and elemental analysis. The products were screened for antibacterial and antifungal activity. Among the series containing some of the compounds showed promising results against standard drugs.