A. Takamizawa, K. Hirai
Apr 25, 1964
Citations
0
Influential Citations
5
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
The reaction of 3-ethoxy-2-methoxymethylenepropionitrile (I) with various kind of amidine gave 2-alkyl (aryl)-4-amino-5-ethoxymethylpyrimidine derivatives. The reaction of 3-ethoxy-2-methoxyethoxymethylpropionitrile (III) with various amidine derivatives afforded 2, 7-dialkyl (aryl)-5, 6-dihydropyrimido [4, 5-d] pyrimidine, which was converted into 2-alkyl (aryl)-4-amino-5-acylaminomethylpyrimidine. The reaction with ethyl 3-ethoxy-2-methoxymethylenepropionate (VI) or ethyl 3-ethoxy-2-ethoxymethoxymethyl-propionate (XXIV) yielded 2-alkyl (aryl)-5-ethoxymethyl-4-pyrimidinol. 2-Phenyl derivative (XXI) was converted into 4-amino compound through 4-chloro compound.