K. Tanji, T. Sakamoto*, H. Yamanaka
May 25, 1982
Citations
0
Influential Citations
6
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
In the palladium-catalyzed cross-coupling reaction of halopyrimidines with terminal acetylenes, 2- and 4-chloropyrimidines can be used as starting compounds, though their reactivity is inferior to that of 2- and 4-iodopyrimidines. The conversion of the 2- and 4-alkynylpyrimidines thus obtained into the corresponding pyrimidinylmethyl ketones was successfully achieved by consecutive treatment with piperidine and oxalic acid dihydrate.