H. Yamanaka, M. An-Naka, Y. Kondo
Oct 25, 1985
Citations
0
Influential Citations
20
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
In the presence of tetrakis (triphenylphosphine) palladium, 2-iodo-4, 6-dimethylpyrimidine and 4-iodo-2, 6-dimethylpyrimidine reacted with ethoxycarbonylmethylzinc bromide (Reformatsky reagent) to give ethyl 4, 6-dimethyl-2-pyrimidineacetate and ethyl 2, 6-dimethyl-4-pyrimidineacetate, respectively. In contrast, the reaction of 5-iodo-2, 4-dimethylpyrimidine with the same reagent resulted in recovery of the starting iodide. Similar results were observed in the reactions of various N-heteroaryl iodides.