H. Agui, T. Komatsu, T. Nakagome
Oct 21, 1975
Citations
0
Influential Citations
14
Citations
Journal
ChemInform
Abstract
The cyclization of m-substituted anilinomethylenemalonates (1) in the presence of polyphosphate ester and some other cyclizing agents gave mixtures of the isomeric ethyl 5- (2) and 7-substituted 4-hydroxy-3-quinolinecarboxylates (3), which led to mixtures of the corresponding quinolinecarboxylic acids (4 and 5) by hydrolysis. The proportions of 4 and 5 in the mixtures were determined on the basis of their nmr spectra. Novel 5-chloro- (8a), 5-methyl- (8b) and 5-nitro-1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids were prepared and evaluated for antimicrobial activities. No significant activity, however, was noted.