M. Legator, K. Palmer, S. Green
Sep 12, 1969
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0
Influential Citations
103
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Quality indicators
Journal
Science
Abstract
Cyclohexylamine, the major known metabolite of cyclamate, was tested in vivo for possible cytogenetic effects. In rats injected with this metabolite, there was a direct relation between dose concentration and percentage of spermatogonial and bone marrow cells showing chromosomal breaks. Single chromatid breaks predominated with infrequent exchange figures.