F. Animati, M. Botta, F. Angelis
Jan 17, 1984
Citations
0
Influential Citations
4
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
3-Bromomethyl-3-cephems are solvolyzed by alcohols, similarly to the Δ2-isomers. The yields are fairly good and this reaction represents a straightforward route to obtain 3-alkoxymethyl-3-cephems.Both 3-bromomethyl-2-cephems and 3-bromomethyl-3-isomers react with a variety of phenols under solvolytic conditions, giving only C-substitution products. This reaction represents the sole example of C-alkylation of phenols by an allylic bromide under such mild conditions.