H. Takeda, K. Shimoyama, M. Misawa
1983
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Japanese Journal of Pharmacology
Abstract
Abstract The authors previously reported that brovanexine, a brom-hexine derivative, is an expectorant possessing both secretagogic action selectively on submucosal gland and mucolytic action toward acid glycoproteins in granules of airway secretory cells. In the present study, the effect of hrovanexine on the secretory activity of type II pneumocytes of rats was investigated biochemically. After treatment with brovanexine or bromhexine at 10 or 20 mg/kg p.o. a day for 1,7 and 14 days, the disaturated phosphatidylcholine (a chief pulmonary surfactant) content in the pulmonary lavage fluid increased. The content of phosphatidylglyceroi,which is a minor surfactant component, also increased after treatments with these drugs for 3 to 14 days, as did the total phospholipid, phosphatidylcholine, protein and saccharide contents. There was no significant difference in the degree of secreta-gogue effects on type II pneumocytes between the two drugs. These findings suggest that brovanexine is expected to be a pulmonary surfactant stimulator like bromhexine.