K. Joshi, A. Dandia, Sangeeta Sanan
Jul 1, 1989
Citations
0
Influential Citations
19
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract The reaction of fluorinated phenylthioureas, with some new fluorine-containing 3-(2-oxocycloalkylidene) indol-2-ones (2) in ethanolic KOH medium, yielded a series of new fluorine containing 5′,6′-cyclopenta-2′-thioxo-3′-phenyl spiro [3H-indole-3,4′(3′H)-pyrimidin] -2(1H)-ones and 2′,4′a,5′,6′,7′,8′,- hexahydro-2′-thioxo-3′-phenyl spiro [3H-indole-3,4′(3′H)-quinazolin] -2(1H)-ones in 55–68% yields. New fluorine-containing 3-(2-oxocycloalkylidene) indol-2-ones (2) were synthesized by the knoevenagel reaction of indole-2,3-diones with cyclic ketones (cyclopentanone/cyclohexanone) in presence of diethylamine as a basic catalyst followed by dehydration in concentrated hydrochloric acid and glacial acetic acid medium. All the compounds have been characterized by their analytical and spectral (IR, 1 H NMR, 19 F NMR and Mass) data.