Xiaofei Chen, Fangjun Xiong, C. Zheng
Sep 2, 2014
Citations
0
Influential Citations
18
Citations
Journal
Tetrahedron
Abstract
Abstract A concise and stereocontrolled synthesis of rosuvastatin calcium has been accomplished, with the key steps including a Keck enantioselective allylation of chloroacetaldehyde with allyltributylstannane to install 5 R -stereocenter and a VO(acac) 2 -catalyzed syn -diastereoselective epoxidation of ( S )-1-chloropent-4-en-2-ol to set the requisite 3 R -chirality.