H. C. Mutreja, G. Saharia, H. Sharma
Feb 20, 1980
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Journal
Defence Science Journal
Abstract
Five substituted dibenzoylmethanes, 1-(p-chlorophenyl)-1-(p-bromophenyl)-, 1-(p-methylphenyl)-, 1-(p-methoxyphenyl)-, and 1-(p-biphenyl)-3-phenyl propane-1:3-diones are coupled with diazotised sulphanilamide, sulphacetamide, N/sup 1/ phenyl-, N/sup 1/p-chlorophenyl-, N/sup 1/p-methylphenyl-, N/sup 1/ p-methoxyphenyl-, N/sup 1/ pyrimidyl-, N/sup 1/ guanidyl-, N/sup 1/-4:6-dimethylpyrimidyl-and N/sup 1/r-pyridylulphanilamides in presence of sodium acetate. All these forty one substituted sulphonamidobenzeneazo 1:3-diketones are crystallised and screened in vitro for their antibacterial properties and some of these are found to be highly active against S. aureus and E. coli.