Zhuang Yan-Xin
2007
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Journal
Chemistry & Bioengineering
Abstract
2,2,6,6-Tetramethylheptane-3,5-dione was synthesized using pinacolone,methyl pivalate as starting material and sodium hydride as base in tetrahydrofuran.The influencing factors on the reaction yield were studied.The optimum reaction conditions were as follows: n(pinacolone)∶n(methyl pivalate)∶n(sodium hydride) 1∶1.5∶3,dropping time of the solution of pinacolone 4 h and refluxing time 8 h.The yield of product was 64.5%.