M. Z. A. Badr, Hassan A. H. El-Sherief, Abdallah Mohamed Mahmoud
1980
Citations
0
Influential Citations
8
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
Synthesis of some 2,3-disubstituted 6-bromo-4(3H)-quinazolinones is described. Treatment of some 4-quinazolinones with phosphorus pentasulfide gave the corresponding 4-quinazolinethiones. The reaction of 6-bromo-2-methyl-3,1-benzoxazin-4-one with hydroxylamine hydrochloride gave 6-bromo-3-hydroxy-2-methyl4(3H)-quinazolinone which on treatment with alkyl halides, acyl chlorides and sulfonyl chlorides gave the corresponding ethers, esters, and sulfonates respectively. 2-Styryl-4(3H)-quinazolinone derivatives are obtained by condensation of aromatic aldehydes and corresponding 3-substituted-6-bromo-2-methyl-4(3H)-quinazolinones. Their antibacterial affinities are of considerable efficiency.