Ved Prakash Bairwa, B. S. Sharma
Jun 14, 2016
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Journal
Indian journal of applied research
Abstract
1,5-benzothizepine moiety shows various biological activities, play a major role in the field of pharmaceutical chemistry, motivate to synthesize new series of 1,5-benzothizepine derivatives. For the synthesis of 8-substituted-2,3-dihydro - 4-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)-1,5-benzothiazepines,equimolar proportion of 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)-2-propenone were reacted with 5-substituted-2-amino benzenethiols, the substituent’s being fluoro,Chloro, bromo, methyl, methoxy, and ethoxy in dry ethanol saturated with dry HCl gas, refluxing for 6 hours obtained in good yield. The structural investigations are based on the result of micro analytical data of elements and spectroscopic studies based on IR, H 1 NMR, and mass spectra.