T. Fujii, S. Sakakibara
Dec 1, 1974
Citations
0
Influential Citations
62
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
Nα-Nps-, Z(OMe)-, Z-, Boc-, and Aoc-derivatives of Nim-tosylhistidine were synthesized as materials for the syntheses of histidine-containing peptides, and the reactivity of the Nim-tosyl group was examined under several conditions commonly used for peptide syntheses. Although the Nim-tosyl group was somewhat more unstable than Nim-benzyl group, the use of the tosyl derivative was found to be advantageous in several points: the enhancement of the solubility of its peptide derivatives, the suppressive effect of racemization during its coupling reactions, and the high removability of the tosyl group under mild conditions.