Zhanyue Wang, D. Du, Di Wu
Jan 5, 2003
Citations
0
Influential Citations
9
Citations
Journal
Synthetic Communications
Abstract
Abstract The synthesis of chiral C 2-symmetric substituted bisoxazoline ligands containing naphthalene group were investigated. Ethyl 2,3-naphthylene-dicarboxylate reacted with amino alcohols and the resulting amides were treated with SOCl2 and then reacted with Et3N in toluene to afford the desired bisoxazolines. 2,3-Naphthylenedicarbonitrile reacted with amino alcohol give N- (1′-phenyl-2′-hydroxyethyl)-2,3-naphthylenedicarboximide 1. The 2,3-naphthylenedicarboxylic acid reacted with thionyl chloride give the 2,3-Naphthalenedicarboxylic acid cyclic anhydride rather than corresponding 2,3-naphthalenedicarboxylic acid dichloride, the former reacted with amino alcohol also give compound 1. The later two strategies cannot give the target bisoxazoline.