P. Nagender, G. M. Reddy, Royya Naresh Kumar
Oct 31, 2013
Citations
0
Influential Citations
4
Citations
Journal
Letters in Drug Design & Discovery
Abstract
The 2-amino-6-trifluoromethyl-3H-pyrimidin-4-one 1 was propargylated to give two regioisomers 2, 3 in defi- nite proportions. Both regioisomers 2 and 3 were independently reacted with alkyl, aryl or cycloalkyl substituted azides under Sharpless conditions and were obtained exclusively 1,4-disubstituted triazole tagged trifluoromethyl substituted pyrimidine derivatives 4 and 5 respectively. All the final products were evaluated for cytotoxic activity against four can- cer cell lines and promising compounds were identified.