Zhang Xin-hua
2004
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Journal
Journal of Nantong Institute of Technology
Abstract
The progress of2,4-dichloro-5-fluoro-acetophenone,which is the intermediate of ciprofloxacin hydrochloride is introduced.Adetailedreviewaboutsynthesis methods,reactionmechanismandsynthesis process of2,4-dichloro-5-fluoroaceˉtophenone is given.It is pointed out that the reduction and improvement of catalyst should be focused on in further study.