J. Hynes, A. Tomažič, C. A. Parrish
Aug 1, 1991
Citations
0
Influential Citations
11
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Recently, we reported that appropriately substituted 2-fluorobenzonitriles undergo cyclization with guanidine carbonate to afford 2,4-diaminoquinazolines usually in good to excellent yield. This paper describes the preparation of a variety of new 2,4-diaminoquinazolines substituted at positions five or seven. In addition, the reactions of selected 2-fluorobenzonitriles with formamidine acetate or acetamidine acetate were examined. The results obtained demonstrate that the analogous 4-amino- and 2-methyl-4-aminoquinazolines can be prepared by this approach but that the yields are considerably lower than when guanidine carbonate is employed as the cyclization reagent.