A. Khodairy
Feb 1, 2007
Citations
1
Influential Citations
18
Citations
Journal
Journal of The Chinese Chemical Society
Abstract
Condensation of l-phenylpyrazolidine-3,5-dione 1 with 3-formylchromone afforded 4-(chromenyl-methylene)pyrazolidinedione 2, which was reacted with hydrazine or hydroxylamine in different molar ratios and conditions to give the corresponding pyrazole and isoxazole derivatives 3-8, respectively. Compound 2 was subject to react with ammonia, N,S- or S,S-acetals, mercaptoacetic acid, cyanoacetamide or cyanothioacetamide to give the corresponding pyridine, dithiine, thiazine and thiophene, 9-14, respectively. The reaction of compound 2 with thiourea, guanidine, cystamine, o-aminothiophenol, ethylenediamine, o-phenelenediamine or barbituric acid afforded the corresponding thiazine, pyrimidine, thiazepine, diazepine, and pyran derivatives 17-23, respectively. The study of the reaction of compound 2 with nucleophiles via chromene ring opening was investigated.