Ding Yan
2004
Citations
0
Influential Citations
0
Citations
Journal
Progress in Pharmaceutical Sciences
Abstract
Objective:To improve synthesis of antibacterial Danofloxacin Mesylate and the important intermediate(1S,4S) -5-methyl-2,5-diazabicyclo[2.2.1]heptane. Methods:The method of the reactions to the side chain after chelation was adopted. Results:The reactions were carried out under very moderate conditions, and the quality was improved. Conclusion:It can be used to manufacture the product on industry scale.