Zhou Yi-hai
2010
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Journal
Anti-infection Pharmacy
Abstract
Objective:To study the synthetic process of cefpiramide in the 3 rd generation cephalosporin antibiotic drugs.Methods:Using 4-hydroxyl-6-methyl-2-pyrone as raw materials,(2R)-2-[4(-hydroxyl-6-methyl-3-pyridine)carboxamide]-2-(4-hydroxyl phenyl)acetic acid was produced,then condensation was conducted with(6 R,7 R)-3-[(methyl-1H-tetrazole-5)sulfenyl]-7-amino-8-oxo-5-thio-1-azabicyclo-[4,2,0]-2-octylene-2-carboxylic acid,and cefpiramide was synthesized.Results:The total yield of reactants was 19.42%,and structure of product was characterized by 1H-NMR,and IR.Conclusion:The synthesis process 1 of cefpiramide described here has advantages of high yield and efficiency.