S. Ogawa, T. Nose, T. Ogawa
1985
Citations
0
Influential Citations
9
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
The antibiotic validamycin A (1a) has been synthesized for the first time (as its undeca-O-acetate) by glycosylation of the partially protected derivative (8) of the aglycone, validoxylamine A (2a), with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl chloride (11), followed by deprotection, thereby establishing the structure previously assigned. The totally O-acetytated derivative (19) of 7-deoxyvalidemycin A has been synthesized in a similar fashion.