Chen Li-gong
2004
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0
Influential Citations
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Citations
Journal
Fine chemicals
Abstract
Synthetic methods for three kinds of Fmoc (9-fluorenylmethoxycarbonyl) amino protective agents were studied:9-fluorenylmethoxycarbonyl chloroformate (Fmoc-Cl),9-fluorenylmethoxycarbonyl azidoformate (Fmoc-N_3) and succinimidyl-9-fluorenylmethoxycarbonyl carbonate (Fmoc-OSu).Fmoc-Cl was obtained from 9-fluorenylmethanol and bis(trichloromethyl) carbonate instead of phosgene.Fmoc-N_3 and Fmoc-OSu were synthesized from Fmoc-Cl separately with triazosodium and N-hydroxysuccinimide in 87.9% and 86.9% yields respectively.Furthermore,Fmoc-glycine was obtained from glycine separately with different Fmoc protective agents in basic condition in the yields of 83.1%,73.3% and 93.9%.The products obtained were analyzed by capillary electrophoresis to give the purity of 97.7%,99.5% and 99.9%.The results indicated that Fmoc-Osu is the best amino protective agent of glycine.