Mo Ling-xua
2013
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Quality indicators
Journal
Anti-infection Pharmacy
Abstract
Objective: To study the anti-tumor effects of 2-(3',5'-dimethoxybenzylidene)-cyclohexanone(IV8) on human cancer cell lines(HeLa,Hep G2,Du145 and SGC7901).Methods: Compound IV8 was evaluated for antiproliferative activities on the above cancer cell lines in vitro by MTT assay.The morphology alteration of Hep G2 was observed under inverted microscope and under AO/EB double staining.Results: Compound IV8 possessed significant inhibitory activity against HeLa,Hep G2,Du145 and SGC7901 with IC50 values of 2.10,11.32,36.50 and 89.53 μmol/L,respectively.Under the microscope,Hep G2 cells produced morphology alteration and cell number decreased significantly.AO/EB double staining found that IV8 group produced apoptotic cells.Conclusion: Preliminary pharmacological tests showed that IV8 had potent anti-tumor activities,which suggested that it was worthy of further studies.