Wang Yongl
2011
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Quality indicators
Journal
Hebei Medical Journal
Abstract
Objective To compare the inhibitory effects of inulicin on the cell growth of mouse hepatoma cell line(H22),mouse sarcoma cell line(S180),human lung adenocarcinoma cell line(A549),human ovarian cancer cell line(SK-OV3) and human cervical cancer cell line(Hela).Methods MTT method was used to detect the inhibitory effects of inulicin on the cell growth of the 5 cell lines mentioned above,and the IC50 was calculated.The effects of inulicin on morphology of the 5 cell lines were observed by using laser scanning confocal microscope and inverted microscope.Results Inulicin inhibited the cell growth of the 5 cell lines in vitro,but the inhibitory effects of inulicin on S180,SK-OV3,H22 and A549 were more obvious than those on Hela cell,with obvious morphological changes being showed by laser scanning confocal microscope and inverted microscope.Conclusion The inulicin has anti-tumor effect and the effect is selective for different cell lines.