Xue Xing-huan, Ma Hongbing, W. Xijing
2009
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Quality indicators
Journal
Chinese clinical oncology
Abstract
Objective:To study the the drug tolerance,tolerated dose of patients and adverse effects of carmofur combined with three-dimensional conformal radiotherapy in patients with esophageal carcinoma and their relationships with the dose of carmofur.Methods:From January 2005 to July 2006,there were 64 patients,4 patients were excluded because of allergy to carmofur in this study,60 patients completed the treatment.Three-dimensional conformal radiotherapy was given.Carmofur was given from 150mg t.i.d.to 200mg t.i.d.during the whole radiotherapy.Results:The main adverse effects were esophagitis,hematoxicity and dermoreaction,which patients could tolerate.The CR rate was 13.3%,PR rate was 65.0%,SD rate was 15.0%,NC rate was 6.7%.The overall response rate was 78.3%(47/60).The median survival time was 16 months,2-year-survival rate was 30.7%.Conclusion:The patients with esophageal cancer can tolerate three-dimensional conformal radiotherapy concurrent with carmofur for 200mg once a time,three times every day.