Liang Zheng-yong
2011
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Journal
Journal of Chemical Engineering of Chinese Universities
Abstract
Disulfides play important roles in biological and chemical studies.Oxidation of thiols is the method most in use for disulfide synthesis,it is because lots of thiols are commercially available and inexpensive.In this study,the thiols were oxidized to series of dialkyl disulfides by using the molybdenum trichloride monoxide-DMSO complex(MoOCl3(DMSO)2) as catalyst and dimethyl sulfoxide as oxidant,and the results show that the mentioned catalyst has the advantages of high catalytic activity,small using amount needed and excellent selectivity.Focusing on the synthesis of di-tert-butyl disulfide,the influences of material ratio,reaction temperature,reaction time and catalyst amount on the yield were investigated.The optimum reaction conditions found are as follows: n(dimethyl sulfoxide) : n(tert-butyl thiol) = 5.5:1,reaction temperature 65℃,reaction time 20 h and catalyst amount 4.7% of tert-butyl thiol molar number,and under above conditions,the yield is greater than 96%.In addition,the reaction kinetics was studied and the kinetic equation was established.In conclusion,the study shows that the proposed method of oxidizing thiols with MoOCl3(DMSO)2 as catalyst is a simple,efficient and mild method for the conversion of thiols to disulfides.