Lu Zheng-qing
2007
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Journal
Food Science and Technology International
Abstract
Sucralose is a kind of high intensity sweetener with significant characteristics. Selecting chlorination of hydroxyl group in sucrose 6-acetate is a key in the process of making sucralose. Sucrose-6-acetate, prepared by using triethyl orthoacetate without crystallization, could be chlorinated by Vilsmeier reagent which was subjected thionyl chloride to DMF. This method had many advantages: high yield, easy operation and easy process. Optimum condition was: reaction temperature 115℃, the mole ratio of SOCl2 and sucrose 6- acetate 10∶1, the ratio of DMF(mL) and sucrose 6-acetate(g)12∶1, reaction time 3h. The structure of the last compound was confirmed by using melting point mensuration, IR and1H-NMR.