Hu Yong-zhou
2008
Citations
0
Influential Citations
0
Citations
Journal
The Chinese Journal of Modern Applied Pharmacy
Abstract
OBJECTIVE To study the crystal structure of 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid.METHODS It was crystalized in glacial acitic acid at 45 ℃.Its single crystal was cultivated and the structure was characterized by X-ray single crystal diffraction analysis.RESULTS AND CONCLUSION The experimental results show that the new crystal structure belongs to triclinic,space group P-1 with unit cell parameters a=5.2879(11)A,b=8.175 4(16),c=16.768(3),α=80.09(3)°,β=89.89(3)°,γ=80.65(3)°,V=704.4(2)A3,Z=2,F(000)=328,μ(Mo Kα)=0.465 mm-1,R1=0.047 7,wR2=0.101 8.It is preferably a crystalline polymorph having a relatively small particle size,which is expected to stabilize the 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid.It is better than amorphous and has better bioactivity and therapeutic actvity.