Hua Wang, Chang-mei Cheng, Hongchao Zheng
Feb 23, 2005
Citations
0
Influential Citations
6
Citations
Journal
ChemInform
Abstract
A novel and convenient procedure for synthesizing 3',5'-dithiothymidine was described. In this procedure, DBU was used to form the intramolecular ring of 2,3'-anhydrothymidine and then the thioacetic acid was used as solvent as well as the nucleophilic reagent to produce S-acetyl-3'-thiothymidine. A very efficient deprotection step was applied to afford the target compound, which can avoid the oxidization of the thiol groups. And the key intermediate, 5'-O-tosyl-2,3'-anhydrothymidine, was found to have regioselectivity for different nucleophiles.