E. Dear, J. Malcolm
Nov 1, 1967
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Influential Citations
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Journal
International journal of neuropharmacology
Abstract
Abstract The action on the central nervous system of 3,4-dimethoxyphenylethylamine (DMPE), a substance reported to be present in the urine of schizophrenic patients, has been investigated. The cortical potentials evoked by stimulation of the right forepaw were used to assess the action of DMPE, when administered both topically and systemically. Topical application produced an increase in the evoked responses, not modified by previous reserpinization, nor by adrenergic a blockers, but blocked by strychnine. The action of DMPE blocked the inhibitory action of topically applied noradrenaline, tyramine and dopamine. The effects of systemic administration were complicated by the accompanying changes in blood pressure, but there is some evidence that DMPE crosses the blood-brain barrier.