Zhang Li
2010
Citations
0
Influential Citations
1
Citations
Quality indicators
Journal
Journal of Tongji University
Abstract
Objective To study the effect of Glycyrrhiza flavonoids(GF) on gastric cancer in vivo, and to provide the theoretical evidence for clinical application.Methods The subcutaneous transplantable tumor models of human gastric cancer in nude mice were established and the anti-gastric cancer effect of GF with different doses were observed during the experiment.Expression of proliferating cell nuclear antigen(PCNA) and mcirovessel density(MVD) were detected by immunohistochemistry at the end of the experiment.Results High dose group of GF had effect of anti-gastric cancer and could reduce the expression of PCNA of tumor cells.Conclusion GF has effect of anti-gastric cancer in vivo,the mechanism may be related with its ability of reducing expression of PCNA of tumor cells.