M. Gaudefroy, J. Pigache
1977
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0
Influential Citations
2
Citations
Quality indicators
Journal
Archives d'anatomie et de cytologie pathologiques
Abstract
Promestriene (3 propyl-ether-17 beta-methyl-ether of estradiol) a new estrogen molecule, conceived for local application has been formulated for gynecological use in a water soluble cream or lotion. The study of 27 women in advanced menopause lasted 20 weeks. In women with severe estrogen deficiencies the local application of promestriene induced a slight maturation of the trigonal or vaginal malpighian epithelium. It limited itself to a small growth of intermediary cells. There was a negligible action on the superficial cells. Linear regression analysis of different indices and maturation values according to Meisels and Hustin shows that even for prolonged treatments, there is little possibility of detrimental estrogenic action.