He Xiao-qian
2015
Citations
0
Influential Citations
0
Citations
Journal
Chemistry & Bioengineering
Abstract
Hydroxyguanidine was synthesized using hydroxylamine sulfate as material,water as solvent,and O-methylisourea hemisulfate as guanidinylation reagent.The optimal reaction conditions were determined as follows:reaction temperature was 0 ℃,reaction time was 8h,molar ratio of O-methylisourea hemisulfate to hydroxylamine sulfate was 1.10,recrystallization solvent was methanol-water(3∶7,volume ratio).Under above conditions,the yield was 54.2%.This process is superior to the traditional process,and it is a green clean synthesis technology.