Feng Yong-bin
2005
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Journal
Fine Chemical Intermediates
Abstract
Through analyzing the mechanism of the hydrolysis of amides,the effects of the hydrolysis on yields of the product were studied.According to the special character of 1-acetamido-3,5-dimethyladamantane,which has big special resistance and substituents pushing electron group.The optimum condition is as follows:hydrolized in alkaline condition,n(reactant)∶n(alkali)=1∶5,the solvent is the mixture of water and ethylene glycol 1∶10(v/v),and the reaction is kept at 150 ℃ for 12 h.The yield of product is 92.5%,the product proption of quality reaches 99.5%。