Lu Ru-mei
2011
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Quality indicators
Journal
Lishizhen Medicine and Materia Medica Research
Abstract
Objective To investigate the hypoglycemic effect of conduritol A from stems of Gymnema sylvestre. Methods Conduritol A(400、200、100 mg·kg-1)was admistered intragastrically for 14 days and its effects on blood glucose,weight and glucose tolerance in diabetic mice and normal mice were observed. Results Conduritol A could significantly decrease fasted blood glucose in diabetic mice induced by alloxan and adrenalin(P0.01).High dosage of conduritol A could decrease fasted blood glucose and weight in normal mice(P0.05).Conduritol A could improve glucose tolerance and the period was about 1 hour.The results of acute toxicity showed that MTD of conduritol A was 750 mg·kg-1,corresponding with 430.29 times of clinical trial daily dose. Conclusion Conduritol A has obvious hypoglycemic effet.